There are multiple medical treatments that can help to alleviate, or at least slow to progression of signs Cognitive Dysfunction Syndrome (CDS).
Anipryl (selegiline hydrochloride) is the first and only drug approved by the FDA to control the clinical signs of CDS. Anipryl is a monoamine oxidase inhibitor that will help to decrease the breakdown of dopamine in the brain, not only making dopamine more available, but also reducing the dangerous, cell-killing free radicals that are produced during dopamine metabolism. Anipryl should not be used concurrently with tricyclic antidepressants (i.e., amitriptyline, clomipramine) or selective serotonin reuptake inhibitors (i.e., fluoxetine). Use with any product containing Amitraz (i.e., Preventic collar, Mitaban dip, Certifect) is also not recommended.
Hill's b/d diet contains antioxidants and omega-3 fatty acids to help protect brain cells from the dangerous free radicals that are generated by the breakdown of dopamine by monoamine oxidase B (MAOB).
S-AdenosylMethionine (SAMe) is a molecule naturally present in the body that is well documented for its effects on membrane fluidity, antioxidant cellular activity and the renewal of certain neurotransmitters in the central nervous system. This molecule is available in a neutraceutical form called Novifit. This form of SAMe is a specific salt that can penetrate the blood-brain barrier for increased efficacy in the brain.
Senilife is another nutritional supplement that is a proprietary mixture containing phosphatidylserine, pyridoxine, Ginkgo Biloba, resveratrol and vitamin E that can help to prevent cognitive decline.
neutricks is a new supplement that is supported by evidence-based research for healthy brain aging. This supplement contains apoaequorin, a jellyfish calcium-binding protein. This supplement was shown to improve learning, accuracy, and enhance attention.
These medical treatment options can be used singly or in combination. Please consult with your veterinarian what might be best for your dog if you suspect your dog has CDS.
Coming up next.. Part III: Behavior modification
My primary objective is to help pets and owners enjoy a more satisfying relationship with each other and maintaining the pet’s health to maintain the pet’s quality of life. Pets have the ability to enrich our lives immensely, and I feel that owners also have a responsibility to enrich their pets’ lives, too.
Got a pet behavior question?
E-mail me at fah@fairmountanimal.com.
